Crystal structure of human thymine DNA glycosylase TDG in complex with a covalent inhibitor (1S, 5R)-C-2711

Crystal structure of human thymine DNA glycosylase TDG in complex with a covalent inhibitor (1S, 5R)-C-2711 Descriptor: (1~{S},2~{S})-2-[(2-methoxy-5-methyl-4-oxidanyl-phenyl)methyl]cyclopropane-1-carboxylic acid, G/T mismatch-specific thymine DNA glycosylase, Small ubiquitin-related modifier 1 Authors: Zhou, J.X, Shao, Z.Y, Zhang, L, Guo, J.N, Wu, H.P, Zhang, L, Du, Y.R, Xu, G.L. Deposit date: 2025-01-13 Release date: 2026-03-11 Last modified: 2026-07-08 Method: X-RAY DIFFRACTION (2.14 Å) Cite: Targeting thymine DNA glycosylase induces synthetic lethality in p53-deficient cancers. Nat.Chem.Biol., 22, 2026