'Hepitopes': A Database of HLA Class I Epitopes in Hepatitis B Virus

This is a spreadsheet containing the results of a systematic literature review to identify and curate all known and putative HLA Class I epitopes in hepatitis B virus (HBV). We performed our literature review in January 2016, searching Medline and Embase via the OVID search interface made available by the University of Oxford. No date restrictions were imposed; Medline was searched from 1946-2016 and Embase from 1974-2016. The relevant subject headings for Epitopes, HLA Antigens, CD8 Antigens and Hepatitis B from the thesauri (MESH and EMTREE) were exploded and searched. In addition the terms epitope* (to pick up singular and plural) and Hepatitis B and HBV were searched in the title and abstract fields. We also identified additional references by searching the bibliographies of relevant articles. As well as details of each citation, we recorded the HBV protein and sequence-numbered location of each epitope (based on a published reference strain; Liu WC, et al. Aligning to the sample-specific reference sequence to optimize the accuracy of next-generation sequencing analysis for hepatitis B virus. Hepatol Int 2016;10:147-157). Each citation was reviewed by a primary reviewer and then again by a second expert to ensure the records are as accurate as possible. Over time, we aim to update and refine the dataset such that it becomes a growing resource for virologists, immunologists and those in the field of vaccine design.A live interactive version can be viewed at http://www.expmedndm.ox.ac.uk/hepitopes.The visualisation code can be viewed at https://github.com/ox-it/hepitopes. As the database is updated and refined, we will submit updated versions to Figshare. In parallel, we have uploaded a static version to Oxford Research Archive (ORA) at the point of initial publication; DOI: 10.5287/bodleian:zr0VAr78q