five

AMPK signaling for naïve pluripotency [Mm]. Mus musculus

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https://www.ncbi.nlm.nih.gov/bioproject/PRJNA357570
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We show activation of AMP kinase (AMPK) with single chemical compounds can endow naïve pluripotency. AMPK activators reverted early-stage differentiating cells or epi-stem cells to naïve state. Moreover, AMPK activators reverted human ESCs to naïve state with pluripotent gene expression profiles and X-chromosome reactivation. Overall design: We analyzed gene expression profiles of mESCs with AICAR during differentiation and reversion
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2016-12-15
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