Crystal structure of allosteric inhibitor, ARQ 092, in complex with autoinhibited form of AKT1
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Crystal structure of allosteric inhibitor, ARQ 092, in complex with autoinhibited form of AKT1 Descriptor: 3-[3-[4-(1-azanylcyclobutyl)phenyl]-5-phenyl-imidazo[4,5-b]pyridin-2-yl]pyridin-2-amine, RAC-alpha serine/threonine-protein kinase Authors: Eathiraj, S. Deposit date: 2016-06-07 Release date: 2016-06-29 Last modified: 2024-11-06 Method: X-RAY DIFFRACTION (2.7 Å) Cite: Discovery of 3-(3-(4-(1-Aminocyclobutyl)phenyl)-5-phenyl-3H-imidazo[4,5-b]pyridin-2-yl)pyridin-2-amine (ARQ 092): An Orally Bioavailable, Selective, and Potent Allosteric AKT Inhibitor. J.Med.Chem., 59, 2016
创建时间：
2016-06-07
