The pKa of 4 acidic-acidic residue pairs obtained from protonation energy at pH 7 (see Materials and Methods for the definition).
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Asp238-Asp350, Glu239-Asp346, Glu220-Asp408, and Glu80-Glu417 in ASIC1 (pKa). These pKa values were obtained by calculating the protonation energy required to protonate the residue by 0.5 H+ at pH 7. Therefore, the values may differ from the apparent pKa values obtained from the titration curves (see the method section for the definition) in Figure 1.
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2015-12-02
