Supplementary Materials

Supplementary Tables (Table S1: GridBox settings for proteins; Table S2: Information on potential targets of 208 P. odoratum active compounds; Table S3: cytoNCA screening for key targets; Table S4: GO functional terms and KEGG enrichment analysis results for the top 2 MCODE network clusters; Table S5: GO functional terms and KEGG enrichment analysis results for 113 potential targets; Table S6: GO functional terms and KEGG enrichment analysis results for 26 targets of levocetirizine acting on pruritus; Table S7: GeneMANIA analysis and GMFA-ED corresponding GO functional terms and KEGG enrichment analysis results; Table S8: Summary of molecular docking scores between P. odoratum targets and those associated with the ErbB signaling pathway and PI3K/AKT pathway; Table S9: Summary table of differentially expressed genes identified after performing differential analysis on GSE6281 and GSE76446 using the GEO2R tool. Supplementary Figures (Figure S1: Comparison of KEGG pathway enrichment for pruritus and GMFA-ED in P. odoratum. (A) KEGG analysis of P. odoratum interaction targets intersecting with pruritus. (B) KEGG analysis of pruritus GMFA-ED targets post-GMFA analysis, with significant enrichment in the ErbB signaling pathway; Figure S2: Molecular docking of 4ejn with MOL000359 and MOL010396, and 3pp0 with MOL000359 and MOL000483. (A) Binding mode of MOL000359 with the 4ejn protein pocket. (B) Binding mode of MOL010396 with the 4ejn protein pocket. (C) Binding mode of MOL000359 with the 3pp0 protein pocket. (D) Binding mode of MOL000483 with the 3pp0 protein pocket. Interaction forces (a), 2D binding mode (b), and binding pocket (c). ).