GENCODE

GENCODE is a scientific project in genome research and part of the ENCODE (ENCyclopedia Of DNA Elements) scale-up project. The GENCODE consortium was initially formed as part of the pilot phase of the ENCODE project to identify and map all protein-coding genes within the ENCODE regions (approx. 1% of Human genome). Given the initial success of the project, GENCODE now aims to build an “Encyclopedia of genes and genes variants” by identifying all gene features in the human and mouse genome using a combination of computational analysis, manual annotation, and experimental validation, and annotating all evidence-based gene features in the entire human genome at a high accuracy.

GENCODE是一项基因组研究的科学项目，也是ENCODE（DNA元素百科全书）扩展项目的一部分。GENCODE联盟最初作为ENCODE项目的试点阶段成立，旨在识别并绘制ENCODE区域（约占人类基因组1%）内的所有编码蛋白基因。鉴于项目初期的成功，GENCODE现致力于构建一个‘基因与基因变异百科全书’，通过结合计算分析、人工注释和实验验证，识别人类和鼠类基因组中的所有基因特征，并对整个人类基因组中的所有基于证据的基因特征进行高精度注释。