Brucella melitensis Genome sequencing. Brucella melitensis

Brucellosis is a major bacterial zoonosis mammalianal animals and humans around the globe. The complete genome sequence of B. melitensis in size of 16M(Rajashekara, Glasner et al. 2004). Four genome sequences including virulent strain B. melitensis M28-12 and vaccine strains B. melitensis M5 and M111 and B. suis S2 have been finished, showing different virulences and pathogenicities(Ding, Pan et al. 2011). Ten species of Brucellosis are clustered into four clades as Brucella abortus-Brucella melitensis, Brucella suis-Brucella canis, Brucella ovis, and Brucella ceti. In addition, Brucella phylogeny does not appear to reflect the phylogeny of Brucella species' preferred hosts. About 4.6% of protein-coding genes seem to be pseudogenes, which is a relatively large fraction. Only B. suis 1330 appears to have an intact beta-ketoadipate pathway, responsible for utilization of plant-derived compounds (Wattam, Williams et al. 2009). A comparison of three genomes of Brucellosis published in Plos One (Crasta, Folkerts et al. 2008) showed 24 genes which may be associated with virulences of Brucellosis abourtus virulent strains. Four genes have an inserts of 60 bp fragment, which is likely associated with the virulence.