Role of yeast Nup60 lysine 467 acetylation in regulation of transcription

Purpose: The experiment aimed to elucidate possible global effects of Nup60 K467 acetylation on transcription in S.cerevisiae. Result: Neither acetyl-mimic nor deacetyl-mimic mutations in Nup60K467 cause major shifts in expression profile.研究目的：本实验旨在阐明Nup60 K467乙酰化对酿酒酵母（S. cerevisiae）转录的潜在全局性影响。实验结果：Nup60K467位点的乙酰化模拟突变体与去乙酰化模拟突变体均未引起表达谱的显著偏移。