Evidence from systematic reviews on non-surgical interventions in AIS, in the order of descending levels of evidence.

CA – cannot apply: LoE impossible to establish due to poor reporting and/or missing data; JBI – Joanna Briggs Institute [49], [50]; ES – electrical stimulation; LESS – lateral electrical surface stimulation; NA – not addressed: such types of SRs are not listed in the OCEBM hierarchy; NNT – number needed to treat; OCEBM – Oxford Centre for Evidence Based Medicine [47], [48]; OMT – osteopathic manipulative treatment;
1for details of the designs of included studies see Table 3; 2the detailed appraisal, with an elaboration, is in Table 1; 3Cochrane review; 4subsequent updates, as explained with Tables 1, 2, 3 and S1; 5one prospective controlled study included; therefore the OCEBM level was graded down one level, according to the classification rules; 6one pilot RCT on 6 IS patients included in the review; therefore the OCEBM level was graded down one level; 7one case study on AIS included in the review; therefore the OCEBM level was graded down one level; 8for details regarding AMSTAR score of this SR see Table 1; 9scored 1b in the JBI classification, but the review was difficult to classify, as it included experimental, observational studies, and SRs; 10various study designs included, see Table 3; 11it was impossible to classify this review, as the authors did not report which specific study designs (except that the included studies were prospective or retrospective) were included or excluded; 12first (former) OCEBM classification; 13no study designs of included studies provided.
Evidence from systematic reviews on non-surgical interventions in AIS, in the order of descending levels of evidence.