The Northern Manhattan Family Study - a Sub-Study of the Epidemiologic Study of Stroke Outcome in 3 Ethnic Groups: The Northern Manhattan Study

The Northern Manhattan Family Study is a sub-study of the Northern Manhattan Study (NOMAS), a population-based cohort study investigating stroke and stroke risk factors among individuals from three ethnic groups residing in northern Manhattan. The overall goal for the Northern Manhattan Family Study was to determine the genetic factors associated with stroke precursor phenotypes. A subset of Caribbean Hispanic probands from the NOMAS Study were selected for inclusion in the family study. Selected probands were at high risk for cardiovascular disease, defined as either 1. Having a sibling with a history of myocardial infarction or stroke, or 2. Having two of the following three risk phenotypes above the 75th percentile in NOMAS; maximal carotid plaque thickness, left ventricular mass or homocysteine level. Probands for the family study were enrolled in northern Manhattan and family members were enrolled at two locations: New York at Columbia University and in the Dominican Republic (DR) at the Clinicas Corazones Unidos in Santo Domingo. A subset of Caribbean Hispanic NOMAS participants were included as a replication sample.]]>
Eligibility criteria for the family study included having a high risk of cardiovascular disease (defined by either 1. Having a sibling with a history of myocardial infarction or stroke, or 2. Having 2 out of 3 risk phenotypes (maximal carotid plaque thickness, left ventricular mass or homocysteine level above the 75th percentile in NOMAS), the ability to provide a family history, obtaining family members’ permission to be contacted by research staff, and having at least three first-degree relatives able to participate.]]>
Name of Grant: Family Study of Carotid Atherosclerosis and Stroke RiskAgency number: NIH R01NS040807PIs: Tatjana Rundek, MD, PhD; Susan H. Blanton, PhD; and Liyong Wang, PhD
Dates: 2001-2023
Specific Aims: Systematically measure stroke precursor phenotypes (SPPs)Determine the heritability of SPPsCollect DNA in family study participants for genome-wide linkage analysisIdentify new QTLs linked to SPPs
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