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PRC2 in Ewing tumors
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创建时间：
2009-04-29
相关数据集
EWS/FLI mediated reprogramming of 3D chromatin promotes an altered transcriptional state in Ewing sarcoma (Hi-C). EWS/FLI mediated reprogramming of 3D chromatin promotes an altered transcriptional state in Ewing sarcoma (Hi-C)
Ewing sarcoma is a prototypical fusion transcription factor-associated pediatric cancer that expresses EWS/FLI or highly related fusions. EWS/FLI dysregulates transcription to induce and maintain sarc
NIAID Data Ecosystem50
PRC2.1 and PRC2.2 synergize to co-ordinate H3K27 tri-methylation.Â
Polycomb Repressive Complex 2 (PRC2) is composed of EED, SUZ12, and EZH1/2 and mediates mono-, di- and tri-methylation of Histone H3 at Lysine 27. While at least two subcomplexes exist, de
NIAID Data Ecosystem50
Tumor suppressor role of Ezh2 in an NRASQ61K driven model of Early T-cell Precursor Acute Lymphoblastic Leukemia (ChIP-Seq)
Purpose: To characterize changes in genome-wide H3K27me3 associated with homozygous inactivation the Polycomb Repressive Complex 2 (PRC2) lysine methyltransferase Ezh2 in a mouse model of earlt T-cell
NIAID Data Ecosystem30
The Ewing Sarcoma Cell Line Atlas - Systematic analysis of genome-wide EWSR1-ETS binding and histone marks in 18 Ewing sarcoma cell lines by ChIP-seq
Cell lines have been essential for major discoveries in cancer including Ewing sarcoma (EwS). EwS is a highly aggressive pediatric bone or soft-tissue cancer characterized by oncogenic EWSR1-ETS fusio
NIAID Data Ecosystem50
The effect of STAG2 loss in Ewing sarcoma [ChIP-seq]. The effect of STAG2 loss in Ewing sarcoma [ChIP-seq]
Ewing sarcoma is an aggressive malignancy characterized by oncogenic rearrangements of the EWS gene with an ETS-family transcription factor, most commonly FLI. Recent comprehensive next-generation seq
NIAID Data Ecosystem40
