Comorbidity–treatment interactions for continuous biomarkers.

This table shows the coefficients and 95% CIs for the comorbidity–treatment interaction continuous biomarkers associated with comorbidity. Biomarkers assessed were estimated glomerular filtration rate (eGFR, as a marker of renal impairment, taken from trial data where this was available and calculated from creatinine, age, sex, and race using the MDRD equations if it was not), body mass index (as recorded or calculated based on height and weight), fibrosis-4 (FIB-4) index (as a marker of liver disease calculated from aspartate aminotransferase, alanine transaminase, and platelet counts), haemoglobin, and MBP (defined as 0.5 × (systolic blood pressure + diastolic blood pressure)). (XLSX)