A–The growth medium, B–the low-conductivity buffer, C–the hyperosmotic buffer, D–the high-conductivity buffer, E–the buffer with calcium. Values in bold and the symbol next to them emphasize if the ce

Figshare2016-09-28 更新30

RIPK1:RIPK3 oligomerizes to form amyloid-like fibrils

细胞信号传导

蛋白质结构

Structural studies showed that activation of RIPK3 by RIPK1 involves the formation of a functional hetero-oligomeric amyloidal signaling complex that mediated programmed necrosis (Li J et al. 2012; Mo

reactome.org30

PDPK1 phosphorylates AKT at T308

细胞信号传导

磷酸化蛋白质

Once AKT is localized at the plasma membrane, it is phosphorylated at two critical residues for its full activation. These residues are a threonine (T308 in AKT1) in the activation loop within the cat

reactome.org40

A Mutation in cnot8, Component of the Ccr4-Not Complex Regulating Transcript Stability, Affects Expression Levels of Developmental Regulators and Reveals a Role of Fgf3 in Development of Caudal Hypothalamic Dopaminergic Neurons

动物神经发育

RNA稳定性调控

While regulation of the activity of developmental control genes at the transcriptional level as well as by specific miRNA-based degradation are intensively studied, little is known whether general cel

Figshare2016-01-15 更新30

IL-3 coordination of myeloblast function by modulating mRNA stability

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