Pharmacokinetics of 111In-DOTA-non-targeted mIFNα2 and 111In-DOTA- targeted mIFNα2 in mouse liver after a single 20 μg/kg intravenous dose.
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In liver, 111In-DOTA- targeted mIFNα2 had a terminal half-life of 67.9 hours, Cmax of 397 ng/g, Tmax of 2 hours, an AUC(0-∞) of 32,474 hr*ng/g, an AUC(0–12) of 4,159 hr*ng/mL and an AUC(0–24) of 7,592 hr*ng/mL. 111In-DOTA-non-targeted mIFNα2 had a terminal half-life of 92.9 hours, Cmax of 259 ng/g, Tmax of 12 hours, an AUC(0-∞) of 31,945 hr*ng/g, an AUC(0–12) of 2,735 hr*ng/mL and an AUC(0–24) of 5,333 hr*ng/mL.Pharmacokinetics of 111In-DOTA-non-targeted mIFNα2 and 111In-DOTA- targeted mIFNα2 in mouse liver after a single 20 μg/kg intravenous dose.
创建时间：
2015-12-03
