Supporting data for "Elucidating Coronavirus and Virus-host Interaction in Bat and Human Intestinal Organoids"

In contrast to various pathologies in human coronavirus infections, bats appear to host coronaviruses in an asymptomatic manner, indicating a distinct profile of virus-host interaction in bats. Moreover, coronaviruses, show enteric tropism in humans and animals, especially in bats, as most bat coronaviruses were identified from fecal specimens.The lack of a robust and biological-relevant in vitro model has been a hurdle for studying numerous bat coronaviruses and elucidating virus-host interactions in human and bat cells. We conducted a series of studies to investigate coronavirus infections and virushost interaction in bat and human intestinal organoids.

与人类冠状病毒感染中的各种病理学相比，蝙蝠似乎以无症状的方式携带冠状病毒，这表明蝙蝠与病毒之间的相互作用具有独特的特征。此外，冠状病毒在人类和动物中表现出肠道嗜性，尤其是在蝙蝠中，因为大多数蝙蝠冠状病毒都是从粪便样本中发现的。缺乏一个稳健且与生物学相关的体外模型一直是研究许多蝙蝠冠状病毒和阐明人类及蝙蝠细胞中病毒-宿主相互作用的障碍。我们进行了一系列研究，以探讨蝙蝠和人类肠道类器官中的冠状病毒感染及其病毒-宿主相互作用。