Inclusion/Exclusion Data and Chart Review Data combined into a single file in Advancing Clinical Trials in Neonatal Opioid Withdrawal Syndrome (ACT NOW) Current Experience: Infant Exposure and Treatment

Data use to determine inclusion in the study, including NOWS score and relative timing of this determination AND Study population data for Infants with NOWS including demographics, patient data and therapy data
Study Description
Despite prevalence of infants exposed to opioids prenatally and who develop NOWS, little evidence exists on the best approaches to identify, monitor, and treat these infants. As a result, there is considerable practice variation across and even within centers. This study systematically collected existing patient-level data, using retrospective chart review, to determine current practices in the care of infants with NOWS at sites associated with ISPCTN and NRN. Data was abstracted from the infants’ records as well as the mothers’ records when her records were available at the site. As a result of the analysis, we have a better understanding of the current practices, and practice variation that exists between these sites. These findings determined the priorities for, and informed the design of, two new clinical trials to improve the care and outcomes for infants with NOWS. Infants of greater than or equal to 36 weeks gestational age with in utero opioid exposure