Top ranked variants by p-value from each genome-wide significant locus in the GMC sample of 6,770 individuals with CF.

The first three rows correspond to loci with SNPs that reached genome-wide significance and the bottom three rows correspond to loci with SNPs that exceeded false discovery rate (FDR) control threshold of q = 0.05 (equivalent to p-7). The top SNP in the SLC6A14 region remains the same at rs3788766 as in [12], while the top SNP at the SLC26A9 locus is now rs7549173. However all significant loci reported at the SLC26A9 locus in [12] are in linkage disequilibrium with rs7549173 (S3 Table), including rs7512462 which has been used as an instrumental variable in a Mendelian Randomization analysis of CF-related diabetes and shown to associate with exocrine pancreas disease [15] and CFTR-directed therapeutics response [2]. The variants in the ATP12A and PRSS1 regions in the previous study [12] are provided in S3 Table. The chromosome 5 and 20 variants are new findings and were not previously identified in [12].