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Engineering of a high-fidelity Cas12a nuclease variant capable of allele-specific editing
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2024-04-29
相关数据集
Allele-specific control of replication timing and genome organization during development [ATAC-Seq]
DNA replication occurs in a defined temporal order known as the replication-timing (RT) program. RT is regulated during development in discrete chromosomal units, coordinated with transcriptional acti
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Additional file 7 of Allele-specific DNA methylation is increased in cancers and its dense mapping in normal plus neoplastic cells increases the yield of disease-associated regulatory SNPs
Additional file 7: Table S6. ASM loci tested for validations by targeted bisulfite sequencing.
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ONT direct RNA sequencing Fast5 files from mouse embryonic stem cell (C57BL/6J x CAST/EiJ) Mettl3 Knockout
We present a novel approach that leverages Oxford Nanopore direct RNA sequencing technology to detect allele-biased patterns of N6-methyladenosine (m6A) modifications in native mRNAs. Our approach uti
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Allele-specific ATAC-seq across 16 neural progenitor cell clones
The two copies of a gene are canonically believed to be indistinguishable to the cell and are expressed in the same spatiotemporal manner in the absence of a loss-of-function mutation. Â The mechanism
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Additional file 11 of Megabase-scale methylation phasing using nanopore long reads and NanoMethPhase
Additional file 11. Mapping of DMRs to the reported MAE genes by Savova et al.
Figshare2021-02-23 更新60
