Transcription factor IRF4 deficiency in NK precursors pre-determines epigenetic changes in mature NK cells
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE283690
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To explore whether IRF4 deficiency determine the epigenetic changes of mature NK cells is at the NKP cell stage, ATAC-seq was performed to analyze chromatin accessibility of NK cells from spleen WT, Irf4-/-, Irf4flox/flox and Ncr1cre+/-Irf4flox/flox mice. We sorted CD3-NK1.1+ NK cells from the spleen of Wilde type C57BL/6 (B6), Irf4–/–, Irf4flox/flox, Ncr1cre+/-Irf4flox/flox mice. These sorted NK cells were subjected to ATAC sequencing
创建时间：
2024-12-11
