Plasmalogen biosynthesis

1-Acylglycerol-3-phosphate is synthesized from dihydroxyacetone phosphate, an acyl CoA molecule and NADPH + H+ in four reactions catalyzed by peroxisomal enzymes, either in the matrix of the organelle or associated with its membrane. These reactions are annotated here for palmityl (C16:0) CoA. In a series of less well-characterized reactions in the cytosol and endoplasmic reticulum, these molecules are converted to ether lipids (plasmalogens). The functions of plasmalogens are not well understood. They are an abundant subclass of phospholipids, however, and defects in their metabolism are associated with serious human disease (de Vet et al. 1999; Nagan and Zoeller 2001).

一酰甘油-3-磷酸由二羟丙酮磷酸、酰基辅酶A分子及NADPH + H+在过氧化物酶体酶催化的四个反应中合成，这些反应可在细胞器的基质中进行，亦或与其膜相关联。此处对棕榈酰（C16:0）辅酶A的这些反应进行了注释。在一系列在细胞质和内质网中较少被表征的反应中，这些分子被转化为醚脂（磷脂酰肌醇）。磷脂酰肌醇的功能尚不明确。然而，它们是磷脂的一个丰富亚类，其代谢缺陷与严重的人类疾病相关（de Vet等，1999；Nagan和Zoeller，2001）。