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Disruption of macrophage cell volume drives inflammatory responses and type I interferon signalling

ChEBI2026-03-15 更新2026-07-12 收录

白细胞功能调控

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https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-MTAB-16723 数据链接链接失效反馈

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Disruption of macrophage cell volume drives inflammatory responses and type I interferon signalling

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2026-03-15

白细胞功能调控

AML靶向治疗

Despite significant efforts to improve therapies for acute myeloid leukemia (AML), clinical outcomes remain poor. Understanding the mechanisms that regulate the development and maintenance of leukemic

NIAID Data Ecosystem80

Structure of apo-SPO1 Tad2

蛋白质结构解析

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Structure of apo-SPO1 Tad2 Descriptor: Gp34.65 Authors: Xiao, Y, Feng, Y. Deposit date: 2023-09-25 Release date: 2024-09-25 Last modified: 2024-12-04 Method: X-RAY DIFFRACTION (2.27 Å) Cite: Single ph

Protein Data Bank Japan2024-12-04 更新50

Effect of TLR Ligation on the Differentiation and Function of Human mMDSC

白细胞功能调控

TLR2信号通路

Effect of TLR Ligation on the Differentiation and Function of Human mMDSC

ChEBI2014-07-21 更新40

Mechanisms Establishing TLR4-Responsive Activation States of Inflammatory Response Genes

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炎症与表观遗传调控

Precise control of the innate immune response is required for resistance to microbial infections and maintenance of normal tissue homeostasis. Because this response involves coordinate regulation of h

NIAID Data Ecosystem60

Gene expression in HeLa cells expressing GFP-IRF3 (non-targeting control and clonal knockouts of DDX58, MAVS, ATP13A1, CAPN15, TADA2B, MED16, and MED24) following Sendai virus (SeV) infection or hpRNA transfection. Gene expression in HeLa cells expressing GFP-IRF3 (non-targeting control and clonal knockouts of DDX58, MAVS, ATP13A1, CAPN15, TADA2B, MED16, and MED24) following Sendai virus (SeV) infection or hpRNA transfection

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CRISPR基因功能筛选

IRF3 translocates from the cytoplasm to the nucleus upon recognition of a cytoplasmic RNA stimulus by RIG-I or MDA5. Using an optical pooled CRISPR knockout screen in HeLa-Cas9 cells, we identified AT

NIAID Data Ecosystem50

Disruption of macrophage cell volume drives inflammatory responses and type I interferon signalling

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