The clinical efficacy of minocycline mouth rinses on recurrent aphthous stomatitis – A randomized controlled trial.

Introduction: Recurrent aphthous stomatitis (RAS) is one of the most common ulcerative diseases affecting the general population. The present study aimed to evaluate the clinical efficiency of 0.5% minocycline mouth rinses prescribed along with the topical anesthetic gel and vitamin supplements over the topical anesthetic gels and vitamin supplements prescribed alone for treating RAS. Materials and methods: A total of sixty participants were randomly divided into two groups, Experimental group: 0.5% Minocycline mouth rinses prescribed along with vitamin supplements and topical anesthetic gel and Control group: Vitamin supplements and topical anesthetic gels alone. The pain symptoms were evaluated using the VAS scores at baseline, and first follow-up visits. The data were analyzed using student t-test. Results: A significant reduction in the pain scores was observed in participants using the 0.5% minocycline mouth rinses prescribed along with vitamin supplements and topical anesthetic gel on the first follow-up visit (p = <0.001). Conclusion: The 0.5% minocycline mouth rinses prescribed along with vitamin supplements and topical anesthetic gel had shown more reduction in the pain symptoms when compared to topical anesthetic gels and vitamin supplements prescribed alone for the treatment of RAS.