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Total Synthesis of (−)-Nakadomarin A

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NIAID Data Ecosystem2026-03-06 收录
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https://figshare.com/articles/dataset/Total_Synthesis_of_Nakadomarin_A/2716243
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A concise diastereoselective total synthesis of (−)-nakadomarin A has been completed in 21 steps from d-pyroglutamic acid. Key steps include an enecarbamate Michael addition/furan-N-acyliminium ion cascade cyclization to provide the tetracyclic core and ring-closing alkyne and alkene metatheses to construct the fifteen- and eight-membered azacycles, respectively.
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2010-11-05
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