DIS3 Mutations Enhance AID-Driven Translocations During B-Cell Activation, Promoting Transformation to Multiple Myeloma

This project contains the custom scripts used in the study investigating the impact of DIS3 mutations on genome stability and translocation landscapes in B cells and plasmacytomas. The work examines how DIS3 dysfunction influences AID-associated DNA damage and structural variant formation contributing to multiple myeloma development.

The code supports structural variant detection from mate-pair and whole-genome sequencing data, breakpoint randomization to generate background models, statistical enrichment testing, and meta-feature analyses integrating sequencing-derived datasets (including DRIP-seq and RNA-seq). The deposited version corresponds to the code used in the associated publication and enables reproduction of the reported analyses.

This software is released under the MIT License. Permission is hereby granted, free of charge, to any person obtaining a copy of this software and associated documentation files to use, copy, modify, merge, publish, distribute, sublicense, and/or sell copies of the software, subject to inclusion of the original copyright and license notice. The software is provided “as is”, without warranty of any kind, express or implied.