Mishra et al., Rehydration rescues <i>Il22</i><sup><em>-/-</em></sup> mice from lethal <i>Citrobacter rodentium</i> infection, 2025
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IL-22 is considered essential for host survival during <i>C. rodentium</i> infection, yet the cause of death was not well understood. Here, we show that <i>Il22</i><sup><em>-/-</em></sup> mice succumb due to dehydration, and that Fluid therapy prevents mortality, revealing IL-22-independent recovery mechanisms. These findings overturn the prevailing paradigm that IL-22 is indispensable for host survival, redefining its role in mucosal immunity.
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figshare创建时间：
2025-10-21
