HVEM in Acute Lymphocytic Leukemia Facilitates Tumor Immune Escape by Inhibiting CD8+ T Cell Function
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE261710
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Our research uncovered that the genetic deletion of HVEM in EL4 can markedly inhibit tumor progress thus prolong survival prognosis of tumor-bearing mouse. Additional experiments also verified that HVEM exerted its oncogenous-effect by constraining the anti-tumor function of T cells in vivo and in vitro. Comparative gene expression profiling analysis of RNA-seq data for Vec-EL4 and HVEM-KO EL4 tumors.
创建时间：
2024-12-31
