Involvement of NK cells and Fc gamma receptors in different kidney allograft rejection types. Involvement of NK cells and Fc gamma receptors in different kidney allograft rejection types

To investigate the involvement of FCGR3A and FCGR2C signaling and NK cell activation during antibody-mediated rejection, we analyzed transcriptomic data obtained by bulk RNA sequencing of kidney allograft FFPE biopsies diagnosed with either antibody-mediated rejection, T-cell mediated rejection or normal biopsies. Overall design: Comparative gene expression profiling analysis of RNA-seq data for antibody-mediated rejection versus T-cell mediated rejection or normal biopsies, seeking NK-cell and FCGR-related transcripts