Spatial Transcriptomics of ageing mouse liver tissues give insights into the zonation-specific lipid deposition

To gain in situ information on the transcriptional profile of the different zones upon ageing, we used the 10X Genomics Visium Platform and ran 5µm tissue cryosections from livers of 2 young and 2 old mice. We investigated the transcriptional events that differentiate lipid metabolism in ageing, across the different zones of the liver tissue.为获取衰老状态下肝脏不同分区的原位转录组谱信息，我们使用10X Genomics Visium平台，对取自2只年轻小鼠与2只老年小鼠肝脏的5μm厚度组织冰冻切片开展实验。本研究针对肝脏组织的不同分区，探究了与衰老过程中脂质代谢差异相关的转录事件。