Pharmacological Induction of a Progenitor State for the Efficient Expansion of Primary Human Hepatocytes

干细胞与再生医学数据中心2022-02-20 更新2024-03-06 收录

肝细胞研究

药理学

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This SuperSeries is composed of the SubSeries listed below.

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2022-02-20

The evaluation of anti-breast cancer activity and safety pharmacology of the ethanol extract of Aralia elata Seem. leaves

抗癌药物

药理学

Aralia elata Seem. is a traditional folk Chinese medicinal plant and its leaves have been used to treat many diseases. We aimed to evaluate the anti-breast cancer activity and safety pharmacolo

DataCite Commons2021-05-17 更新320

Additional file 2 of Network pharmacology-based study on the mechanism of Yiganling capsule in hepatitis B treatment

药物筛选

药理学

Additional file 2: Table S2. Compounds with an oral bioavailability value greater than 30%. Table S3. Compounds with a Caco-2 value > − 0.4. Table S4. Compounds with a drug-likeness value > 0.18

DataCite Commons2024-02-15 更新130

2018-2020年广东黑果腺肋花楸花色苷稳定性与辐射保护作用的研究数据集

植物化学

药理学

（1）不同提取条件对黑果腺肋花楸花色苷的提取效果影响；（2）不同储存环境对黑果腺肋花楸花色苷的稳定性及抗氧化性影响；（3）黑果腺肋花楸花色苷对辐射小鼠氧化损伤防护作用

中国科技资源共享网2026-07-12 更新120

The essential oil of Hyptis crenata Pohl ex Benth. presents an antiedematogenic effect in mice

药理学

炎症研究

Hyptis crenata, commonly known as “salva-do-Marajó”, “hortelã-do-campo”, and “hortelãzinha”, is used in folk medicine in Northeast Brazil as tea or infusion to treat inflammatory diseases. Due to the

DataCite Commons2021-03-26 更新160

免疫因子IL6可在体外长期扩增肝细胞

肝细胞研究

免疫因子应用

鉴于肝细胞在临床治疗，药物筛选和药物安全性评价等方面的应用价值，对肝细胞的体外扩增机制及方法的研究具有重要意义。在此项研究中，我们通过筛选体内调节肝脏再生的细胞因子，发现利用IL-6结合EGF和HGF（IL6培养基）即可诱导小鼠原代肝细胞在体外大量扩增，并可以接近无限传代（论文发表时已>50代）。通过实验及估算，肝细胞可以在150天内扩增约1035倍。我们发现，肝细胞在扩增过程中会去分化为肝祖细胞

干细胞与再生医学数据中心2023-04-28 更新130

Pharmacological Induction of a Progenitor State for the Efficient Expansion of Primary Human Hepatocytes

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