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Genome-wide DNA methylome analysis identifies putative biomarkers associated with the survival of human ovarian cancers [30 cases]

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NIAID Data Ecosystem2026-03-12 收录
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE168921
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We conducted an epigenome-wide association study (EWAS) to evaluate global DNA methylation in EOC. In a retrospective cohort of 30 HGSOC subtype primary ovarian cancers, we observed that global DNA hypermethylation was preferentially associated with recurrent HGSOC. A total of 2,969 DMPs corresponding to 1,471 genes were involved in olfactory transduction, and calcium and cAMP signaling. Whole-genome DNA methylation analysis was performed on a retrospective cohort of 30 HGSOC patients with platinum-sensitive and platinum-resistant samples. contributor: Centre for PanorOmic Sciences (CPOS), Genomics Core, HKU
创建时间:
2021-08-12
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