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Palladium-Catalyzed Diastereoselective Synthesis of 3‑Arylbutanoic Acid Derivatives

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Figshare2017-11-02 更新2026-04-29 收录
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https://figshare.com/articles/dataset/Palladium-Catalyzed_Diastereoselective_Synthesis_of_3_Arylbutanoic_Acid_Derivatives/5565283
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The first palladium-catalyzed diastereoselective conjugate addition of arylboronic acids to chiral imides is reported. The catalytic system employing 4-tert-butyloxazolidin-2-one as the chiral auxiliary in a mixed solvent system of MeOH/H2O (1:3) under an air atmosphere provides the optically active 3-arylbutanoic acid derivatives in excellent yields with high diastereoselectivity.
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2017-11-02
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