Associations of C. trachomatis, N. gonorrhoeae, T. vaginalis and active syphilis (high-titre) with sociodemographic, behavioural and biological factors in a cohort of women at increased risk for HIV acquisition in northwestern Tanzania.

Note: C. trachomatis, N. gonorrhoeae and T. vaginalis data from all visits were used in the analysis. For active syphilis (high-titre), data only from the enrolment visit were used since there were very few incident infections. “1” denotes the reference category throughout.[1] ORs for sociodemographic variables adjusted for visit month, town, age and duration working in facility type; ORs for behavioural variables adjusted for these sociodemographic variables, number of lifetime partners and contraception; ORs for biological variables adjusted for these sociodemographic and behavioural variables, ever pregnant and gonorrhoea status (the results for these variables are shown in bold). Full results from each level shown in Table S1 in File S1.[2] ORs for sociodemographic variables adjusted for visit month, town and age; ORs for behavioural variables adjusted for these sociodemographic variables and AUDIT; ORs for biological variables adjusted for these sociodemographic and behavioural variables, ever pregnant and chlamydia status (the results for these variables are shown in bold). Full results from each level shown in Table S2 in File S1.[3] ORs for sociodemographic variables adjusted for visit month, town, age, education and marital status; ORs for behavioural variables adjusted for these sociodemographic variables (no behavioural variables included); ORs for biological variables adjusted for these sociodemographic and behavioural variables and current vaginal microbiota assessed by Nugent score (the results for these variables are shown in bold). Full results from each level shown in Table S3 in File S1.[4] ORs for sociodemographic variables adjusted for visit month, town, age and education; ORs for behavioural variables adjusted for these sociodemographic variables and whether had concurrent partners in the last 3 months; ORs for biological variables adjusted for these sociodemographic and behavioural variables and T. vaginalis status (the results for these variables are shown in bold). Full results from each level shown in Table S4 in File S1.[5] Combined complete primary and secondary since only two women who attended secondary school had active syphilis (high-titre) at enrolment.[6] Based on responses to ten AUDIT questions. Scores based on responses to each question: 0–7 = non-drinker or low-risk; ≥8 harmful or hazardous drinking.[7] Combined positive (from baseline) and positive (seroconverted during follow-up).[8] Current syphilis status is defined as follows: RPR negative/RPR positive and TPPA negative = never infected (includes biological false positives); RPR negative and TPPA positive = previous infection; RPR positive and TPPA positive = active infection.[9] All women HIV-negative at enrolment as per eligibility criteria.