SntB triggers the antioxidant pathways to regulate development and aflatoxin biosynthesis in Aspergillus flavus. SntB triggers the antioxidant pathways to regulate development and aflatoxin biosynthesis in Aspergillus flavus

In this study, sntB gene deletion (ΔsntB), complementary (Com-sntB), and HA tag fused to snt2 strain (snt2-HA) strains were constructed by using the homologous recombination method, respectively. It was found in this study that SNTB plays a key role in development, secondary metabolism and pathogenicity of A. flavus. The mechanism was explored by Chromatin immunoprecipitation sequencing (ChIP-seq) and RNA sequencing (RNA-seq). Overall design: To reveal the potential complex regulatory network of the sntB, RNA-seq analysis was carried out on the WT and ΔsntB strains. ChIP-seq analysis was carried out on the WT and sntB-HA strains.