Tip60 HAT action mediates environmental enrichment induced cognitive restoration

ChEBI2016-01-07 更新2026-07-12 收录

乙酰化调控

认知功能恢复机制

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Tip60 HAT action mediates environmental enrichment induced cognitive restoration

创建时间：

2016-01-07

A variant NuRD complex containing PWWP2A/B excludes MBD2/3 and directs HDAC activity to regulate histone acetylation and RNA Pol II dynamics

乙酰化调控

转录动力学

Transcriptional regulation by chromatin is a highly dynamic process directed through the recruitment and coordinated action of epigenetic modifiers and readers of these modifications. Using an unbiase

NIAID Data Ecosystem100

PDHE1α, PARylation, Acetyl-CoA, Acetylation, Histones, DNA damage repair

DNA损伤修复机制

乙酰化调控

Chromatin relaxation is a prerequisite step that allows the DNA repair machinery to access double-strand breaks (DSBs), and local histones around the DNA breaks suffer from prompt acetylation changes.

NIAID Data Ecosystem10

Components of the Tip60 HAT complex control the sperm/oocyte decision.

卵泡发育

乙酰化调控

A. Analysis of the PCAF/SAGA HAT complex. B. Analysis of the Tip60/NuA4 HAT complex. The phenotypes are Fog (feminization of the germ line), Emb (embryonic lethal) and Ste (Sterile). C. briggsae genes

NIAID Data Ecosystem10

Epigenetic Regulation of Nuclear Lamina-Associated Heterochromatin by HAT1 and the Acetylation of Newly Synthesized Histones [imMEF_ATAC_Seq]

染色质可及性分析

乙酰化调控

We report that HAT1 regulates chromatin accessibility of large chromosomal domains. Measuring chromatin accessibility in HAT1 WT and KO imMEFs by ATAC-Seq

NIAID Data Ecosystem30

The reducing equivalent NADPH dictates histone acetylation via direct inactivation of HDAC3. The reducing equivalent NADPH dictates histone acetylation via direct inactivation of HDAC3

乙酰化调控

HDAC3失活机制

NADPH has been long well-recognized as a key cofactor for antioxidant defense and reductive biosynthesis. Here we report a metabolism-independent function of NADPH in modulating epigenetic status and

NIAID Data Ecosystem10

Tip60 HAT action mediates environmental enrichment induced cognitive restoration

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