Prospective Investigation of Pulmonary Embolism Diagnosis (PIOPED-BioLINCC)

Data Access NOTE: Please refer to the “Authorized Access” section below for information about how access to the data from this accession differs from many other dbGaP accessions. Objectives: To determine the sensitivities and specificities of ventillation/perfusion (V/Q) lung scans for acute pulmonary embolism (PE).Participants: A total of 1487 participants were enrolled.Conclusions: Almost all participants with pulmonary embolism had abnormal scans of high, intermediate, or low probability, but so did most without pulmonary embolism. Only in a minority of participants did the clinical assessment combined with the V/Q scan interpretation improve the overall chance of reaching a correct diagnosis of acute PE. Although a high probability scan usually indicated the presence of PE, only a small number of participants with PE had a high probability scan. Reference: PIOPED Investigators, 1990, PMID: 2332918. ]]>
Eligible participants were 18 years of age or older without contraindications for pulmonary angiography, and for whom a request was made for a V/Q scan or a pulmonary angiogram. A total of 1,487 participants provided consent to participate in PIOPED and the analysis was conducted in a random sample of 933 participants. Participants suspected of pulmonary embolism underwent a ventilation-perfusion scan. Participants with an abnormal perfusion scan underwent angiography. All participants were followed for one year.]]>