Histopathological changes in placenta in late IUFD cases

My Research question was "Does placenta of late intrauterine fetal death exhibits any specific histopathological changes?"
Objectives were:
a) To evaluate placental histopathological changes in late IUFD.
b) Staging of maternal & fetal inflammatory responses found in placenta of late IUFD.
c) To interpret the immunohistochemical expression of CD15 in placenta in some
selected late IUFD cases and its grading.
d) To see the association between CD15 immunopositivity and delayed villous
maturation in placenta of late IUFD cases.
A cross sectional study was carried out in the Department of Pathology, SSMC among the late IUFD cases in the Obstetrics and Gynecology department of Sir Salimullah Medical College Mitford Hospital, Dhaka during March 2021 to January 2023. A total of 80 admitted cases of diagnosed late IUFDs were included in this study. Pregnant women aged between 19 to 44 years and presented at or after 28 completed weeks of gestation were enrolled in this study. Written consent was taken from those who agreed to participate in the study. Respective placentas of the deadborns were histopathologically analyzed and CD15 immunohistochemical expression was observed in selected cases. Statistical analyses of the results were obtained by using window based computer software devised with Statistical Packages for Social Sciences (SPSS-26). This data stated that late IUFD do have significant placental histopathological abnormalities & distinctive pattern of CD15 immunohistochemical expression.