Mean DNA methylation levels for hypermethylated genes sorted by group.

A. Genes commonly methylated in >95% of all samples. B. Genes methylated in all tumorous samples (including MCRC). C. Genes methylated only in LGD, HGD and stage I-III CRC. D. Genes individually methylated in certain groups. Y: young normal, N: adult normal, CN: macroscopically normal tissue taken from at least 10 cm away from the tumor margin, F: macroscopically normal tissue taken from 1 cm away from the tumor margin, LGD: low-grade dysplasia, HGD: high-grade dysplasia, CRC: colorectal cancer, MCRC: metastatic CRC, UCi: inactive ulcerative colitis, UCa: active ulcerative colitis. Bold: genes hypermethylated in more than half of the samples in the representative group. Mean DNA methylation levels for hypermethylated genes sorted by group.