The incidence and lung tumor multiplicity of lung tumor formation in A/J mice treated with NNK, NNK combined with TCDD, E2, or both.
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* Significantly higher (p<0.05) compared to Sham, control groups. †Significantly higher (p<0.05) compared to Sham, NNK groups. #Significantly higher (p<0.05) compared to OVX, NNK groups. ‡Significantly higher (p<0.05) compared to OVX, NNK+TCDD groups. §Significantly higher (p<0.05) compared to OVX, NNK+E2 groups. Tumor incidences are given as the number of animals with tumors/total number of animals at risk (%). Tumor multiplicity is the average tumor number on tumor-bearing mice. Data of lung tumor multiplicity are given as the mean ± SEM. *significantly higher (p<0.05) compared to Sham, Control groups, #significantly higher (p<0.05) compared to OVX, NNK groups, †significantly higher (p<0.05) compared to Sham, NNK groups, ‡significantly higher (p<0.05) compared to OVX, NNK+TCDD groups, §significantly higher (p<0.05) compared to OVX, NNK+E2 groups.
