Amino acid changes present after triple therapy with TEL and BOC in 21 patients without SVR.

*Letter on the left represents the wild type amino acid (aa), on the right, the aa substitution. Amino acid changes known to confer resistance to PI's are reported in bold and other observed sequence variants are shown in italics. **Clonal analysis revealed 1 clone with the resistance mutation V55A. +Only found as a minor quasispecies pre-treatment. ++I170V has been described as a polymorphism not associated with resistance in GT3. GT; genotype, BT; Breakthrough. NR; Non-response. RL; Relapse. Amino acid changes present after triple therapy with TEL and BOC in 21 patients without SVR.