Tissue levels of AT2220 in hP545L GAA Tg/KO mice following four-week daily oral administration.
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Eight-week old male hP545L GAA Tg/KO mice were administered AT2220 ad libitum in drinking water for four weeks at the indicated doses. Tissues were collected at the indicated times post-AT2220 withdrawal, and AT2220 levels were quantitated using LC-MS/MS as described in ‘Materials and Methods’. AT2220 concentrations are expressed as nM, and represent the mean ± SEM for groups of 7 mice. LLOQ: lower limit of quantitation (184 nM).
创建时间：
2015-12-02
