Cognate T cell interactions affect the DC transcriptome [dataset 4]
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE129214
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Our data suggest that peptide-presenting DC receive signals from synapse-forming antigen specific CD4+ or CD8+ T cells that alter the DC expression profile. To further test this notion, we hock immunized T cell-engrafted mice with NP harboring CpG and coated with OVA (OVA / CpG NP) or the control antigen BSA (BSA / CpG NP) and isolated NP+ DC for RNAseq. NP+ DC were isolated 20 hrs post sub-cutaneous immunization with (OVA/CpG) NP or (BSA/CpG) NP from popliteal and inguinal lymph nodes. (OVA / CpG) or (BSA/CpG) NP+ DC were single-cell sorted into 384w-plates, barcoded and MARS-sequenced.
创建时间：
2019-04-04
