Self-Exfoliated Guanidinium-Based Ionic Covalent Organic Nanosheets (iCONs)

Covalent
organic nanosheets (CONs) have emerged as functional two-dimensional
materials for versatile applications. Although π–π
stacking between layers, hydrolytic instability, possible restacking
prevents their exfoliation on to few thin layered CONs from crystalline
porous polymers. We anticipated rational designing of a structure
by intrinsic ionic linker could be the solution to produce self-exfoliated
CONs without external stimuli. In an attempt to address this issue,
we have synthesized three self-exfoliated guanidinium halide based
ionic covalent organic nanosheets (iCONs) with antimicrobial property.
Self-exfoliation phenomenon has been supported by molecular dynamics
(MD) simulation as well. Intrinsic ionic guanidinium unit plays the
pivotal role for both self-exfoliation and antibacterial property
against both Gram-positive and Gram-negative bacteria. Using such
iCONs, we have devised a mixed matrix membrane which could be useful
for antimicrobial coatings with plausible medical benefits.

共价有机纳米片（CONs）作为一种功能化的二维材料，已广泛应用于多种领域。尽管层间的π-π堆积、水解不稳定性以及可能的重新堆积阻碍了它们在由结晶多孔聚合物组成的薄层CONs上的剥离，但通过内在离子桥接的设计，我们预见到合理构建的结构或许能够解决这一问题，从而在不借助外部刺激的情况下产生自剥离的CONs。为了解决这一问题，我们合成了三种具有抗菌性能的自剥离胍盐基离子共价有机纳米片（iCONs）。自剥离现象得到了分子动力学（MD）模拟的支持。内在的离子胍单元在自剥离和对抗革兰氏阳性及阴性细菌的抗菌性能中发挥着关键作用。利用这些iCONs，我们设计了一种混合基质膜，该膜有望用于抗菌涂层，并具有潜在的医疗效益。