Myriocin and rapamycin generate a synergistic increase in lifespan.

† Values represent the concentration of individual drugs necessary to produce the same degree of survival as the combination treatment and were calculated from dose response curves.¶ Survival represents the fraction of cells viable after 48 hrs of incubation (CLS Day1) divided by the survival after a further 32 hrs of incubation.‡ The drug combination (150 nM myriocin + 50 nM rapamycin = 60 ng/ml myriocin + 46 ng/ml rapamycin) shown in this row was used to generate the lifespan data shown in Fig. 1A and other experiments labeled with the term ComboDT.§ Underlined values represent drug combinations in the corresponding row that give additive or antagonistic effects.Myriocin and rapamycin generate a synergistic increase in lifespan.