small RNA profile of human brain tissues

Fragments of mature tRNAs have long been considered as mere degradation products without physiological function. However, recent reports show that tRNA-derived small RNAs (tsRNAs) play prominent roles in diverse cellular processes across a wide spectrum of species. As it is the case for other classes of small RNAs, tsRNAs were found to affect gene expression in different contexts, but the mechanisms behind these effects appear more diverse, more complex and are generally less well understood. In addition, surprisingly little is known about the expression profiles of tsRNAs across different tissues and species. Therefore, we analyzed available and own sRNAseq data to provide an initial overview of tsRNA expression in different species and tissues. Aim of this sequencing project was to analyze the small RNA profile of human brain tissues. Overall design: small RNA sequencing of libraries generated from the human hippocampus, cortex and cerebellum.