cGMP is degraded by PDEs

Cyclic GMP phosphodiesterase are hydrolases selective for cAMP (PDE4, 7 and 8), cGMP (PDE5, 6 and 9) or able to hydrolyse both cAMP and cGMP (PDE1, 2, 3, 10 and 11). The dual-specificity PDEs allow for cross-regulation of the cAMP and cGMP pathways, e.g. PDE2 can hydrolyse both, but binding of cGMP to the regulatory GAF-B domain increases cAMP affinity and hydrolysis.<br>PDE2, 3 and 5 are expressed in platelets.

环状GMP磷酸二酯酶是一类对cAMP（PDE4、7和8）、cGMP（PDE5、6和9）具有选择性的水解酶，或者能够同时水解cAMP和cGMP（PDE1、2、3、10和11）。这类具有双重特异性的PDE酶允许cAMP和cGMP途径之间的交叉调节，例如，PDE2能够水解两者，但cGMP与调节性GAF-B结构域的结合会增强对cAMP的亲和力和水解作用。<br>PDE2、3和5在血小板中表达。