Investigation of interaction between bacteria and phages. Escherichia coli

Antimicrobial-resistant bacteria have spread rapidly all over the world and are an important global health issue. Inappropriate use of antibiotics is one of the reasons of their occurrence. In this context, phage therapy, by using bacteriophages which specifically infect to bacteria, has been received significant attention as an alternative approach to classical antibiotic therapy. On the other hand, further understandings of interaction between bacteria and phages are required to develop phage therapy because bacteria can acquire phage-resistance in the therapy. To investigate mechanisms underlying phage infection to the host and identify the receptors, whole genome information is necessary. This study will facilitate the understandings of life cycle of phage and phage-resistance.