Supplementary Material for: Multiorgan Dysfunction in Severe Acute Pancreatitis: A Case of Septic Shock, Renal Cortical Necrosis, and Takotsubo Cardiomyopathy

Severe acute pancreatitis (AP) may evolve rapidly into systemic inflammatory response syndrome (SIRS) and multiorgan dysfunction syndrome (MODS), posing significant management challenges. We present a rare and complex case of severe AP complicated by septic shock, bilateral renal cortical necrosis (RCN), and Takotsubo Cardiomyopathy (TTC). Septic shock contributed to profound hemodynamic instability, while RCN—a rare and often fatal form of acute kidney injury (AKI)—added to the severity of renal dysfunction. Concurrent TTC, likely precipitated by catecholamine surges during critical illness, led to transient myocardial dysfunction. This case highlights the importance of early recognition, a multidisciplinary approach, and advanced critical care strategies, including SLED with hemoadsorptive filters, to improve outcomes in patients with severe AP complicated by rare systemic manifestations.