Additional file 1 of The causal associations of circulating amino acids with blood pressure: a Mendelian randomization study

Additional file 1: Table S1. Overview of observational studies investigating associations of amino acids with blood pressure or hypertension. Table S2. Definitions and the unique data identifiers within UK Biobank data. Table S3. Characteristics of the instrumental variables for circulating levels of amino acids in primary analyses. Table S4. Association of selected SNPs in our primary analyses with potential confounders. Table S5. Characteristics of the broad sets of instrumental variables for circulating levels of amino acids in sensitivity analysis. Table S6. Characteristics of instrumental variables for SBP, DBP and hypertension in reverse MR analyses. Table S7. Characteristics of participants from UK Biobank included in the MR analyses. Table S8. Causal effects of circulating levels of amino acids on BP and hypertension using different methods. Table S9. Causal effects of circulating levels of amino acids on BP and hypertension using the broad sets of instrumental variables. Table S10. MVMR estimates the independent effects of BCAA and glycine on SBP, DBP and risk of hypertension. Table S11. Causal effects of BP and hypertension on circulating levels of amino acid using different methods.