Raw data for Association of ACE2 gene functional variants with gestational diabetes mellitus risk in a southern Chinese population

These data were generated to investigate the association and functional
analysis of angiotensin-converting enzyme 2 genetic variants with the
pathogenesis of Gestational diabetes mellitus (GDM). This study conducted
a case-control study involving 569 GDM patients and 735 healthy pregnant
women to explore the associations between candidate variants in the ACE2
gene variants and the pathogenesis of GDM. This study collected clinical
samples and data, and used logistic regression, false positive report
rate, multi factor dimension reduction, functional analysis and other
analysis methods to process the research data. Potential functional ACE2
gene variants (rs2106809 A>G, rs6632677 G>C, and rs2074192
C>T) were selected and genotyped using kompetitive allele-specific
PCR. The strength of the associations between the studied genetic variants
and the risk of GDM were evaluated using odds ratios (ORs) and
corresponding 95% confidence intervals (CIs). Finally, ACE2 gene variants
are significantly associated with the risk of GDM via gene-gene and
gene-environment combination. The rs2074192 C > T affects the
splicing of ACE2 gene, which may be a potential mechanism leading to the
altered susceptibility of individual female during pregnancy in Guilin to
GDM